III Mannino

in fabrica PCs de CXX., I fasciculum in a Deteret invalidos aut phialam suam in cardboard XX et X quam at pede., III stipant a Deteret invalidos cardboard.

in fabrica PCs de CXX., I fasciculum in a Deteret invalidos aut phialam suam in cardboard XX et X quam at pede., III stipant a Deteret invalidos cardboard.

in fabrica PCs de CXX., I phialam suam in actis diurnis proscribat aut Deteret invalidos cartons XX PCs., in charta cartons I, II, III, IV et VI papularum, lucentis maculæ.

Farmacocinética

Post recessum ab omni paene raptim ingestion 3.5 Manin gastrointestinal tractus servatur. Mikroionizirovannogo release integram substantiam capit ex loci activae in V min.
XCVIII% ad 3.5 plasma dapibus binding plus quam Manin, XCV%.
Duae formae paene otiosum metabolized iecoris tenuissimum quarum depellantur renes alterum - bilem.
T1 / 3.5 ad II horas 1.5-3.5 Mannino est.

Dosing

3.5 Manin viva voce capta est vespere et mane, ante cibo, non cibum. Et constituta est per se dosis fretus in severitatem morbo.
Et initiali, dose of - I / 2-1 Tabula Pro Medium -. Tabula I. per day, maximus - III, in casibus exceptionalibus - videre Tabula IV. per day.
Bibitur Daily usque ad II tabulas. typically unus tollet (mane), altior - sit divisa doses in II (mane et vespere).

Parte effectus,

Hypoglycemia potest (cum exsiliens prandium, pharmacum dose, cum consectetur corporalis exercitatio, tum ex usu alcoholis intensive).
Tractus de digestivorum: interdum - nausea, vomitus, et in casibus nonnullis - cholestatic ictero, Hepatitis.
Hemopoiesis ratio ex, raro admodum - thrombocytopenia, granulocytopenia, erythropenia (usque ad pancytopenia), in quibusdam casibus - hemolytic anemia.
Allergic reactiones Parcius - cutis temere, febrem, iuncturam dolor, proteinuria.
Alter: at principium curatio potest perturbare transit accommodationem. In rara casibus - photosensitivity.

Contraindications

Contraindications ad usum medicamento 3.5 Manin Sunt, hypersensitivity (including sulpha ad medicamentorum et aliarum sulfonylurea derivationes) type I diabetes Mellitus (insulin dependens), metabolicae decompensation (ketoacidosis, precoma, COMA), status post Tumor ex pancreate, renibus et iecur morbo gravibus, aliquid acutis statu (exampla: decompensation metabolismi carbohydratorum in infectiones morbis ardet, iniurias vel post surgery, ubi ostensum est major insulin tenens), leukopenia, TORMENTUM demptis s stomachum, state, et cibus comitatus per progressionem de hypoglycemia malabsorption, gravida et pectus-pascens.

Commercio cum aliis medicaménta utíliter

In hypoglycemic effectus confortans in pharmacum 3.5 Manin dum fieri potest taking ACE inhibitors, anabolic agentibus masculum sexus Hormones et alios oralis hypoglycemic agentibus (exampla: acarbose, biguanides) et insulin, azapropazone, NSAID, beta-blockers, quinolone derivatis, chloramphenicol, et clofibrate analogs ejus derivationes Alcaloide, disopyramide, fenfluramine, antifungal medicamenta (Miconazole, fluconazole), fluoxetine, MAO inhibitors, pascha pentoxifylline (c parenteral excelsum dose Edenis), perhexiline, pyrazolone derivatis, phosphamide (exampla: cyclophosphamide, ifosfamide, trofosfamide), probenecid, salicylates, sulfonamides, et tetracyclines tritokvalinom.
Vrina acidifying agentium (Ammonium chloride, calcium chloride) de medicamento effectus ad augendae sui parentum provocant dissociationem per reducendo gradum John quod reabsorption proventus ejus.
Hypoglycemic Mannino agendi medicamento potest aliquid reduci in usum barbiturates, Isoniazid, diazoxide, corticosteroids, glucagon nicotinate (summus dose), phenytoin, phenothiazines, Rifampicin, thiazide urinam cient, acetazolamide, oralis contraceptives, estrogens, thyroideum hormone medicinae, Simpaticomimetico agentibus, calcium channel patiens blockers, lithium sales.
H2 receptor antagonists potest attenuatis in una parte, et alter ad augendae hypoglycemic effectum Mannino præparátio ejus.
Quam in rara casibus Pentamidine minui nec augeri potest gravi de concentratio Glucosum in sanguine.
Cum applicantur cum eodem medicamento aut augere possunt, nullius minuat Mannino Alcaloide derivata ab opus.
Cum per confirmationem percipiant hypoglycemic actio of beta-blockers, clonidine, et guanethidine reserpine, adiumenta et medicamenta tormenta sunt a centralis mechanism de actio, posse quidem infirmare sensus praecursores symptomata de hypoglycemia.

Hesi

Cum progressum hypoglycemia aegros potest perdere et imperium auto-conscientia et ex hypoglycemic progressus coma.
Curatio: Mitis hypoglycemia patientes estote glutiam salivam est a piece of sugar, cibus vel potus in excelsum sugar (jam, mel, dulcis tea et vitrum). Si sciat oportet intrare in / GLYCOSA - 40-80 g dextrose XL% (GLYCOSA), tunc influxus 5-10% dextrose. Vos can tunc adiuncta glucagon I mg / in / m et m / k. Si non patientes estote ad conscientiae, hunc modum potest iterari, etc., potest requirere intensive cura.

Forma release

Manin 3.5 - Tabulettae.
Packaging -. CXX corporis fabrica per unitates in charta cartons vel XXX ad LX pieces.

I tabula 3.5 Mannino Activae continet substantiae glibenclamide (micronized per speciem) 3.5 mg forma.
Excipients: lactose monohydrate, Capsicum annuum amuli, gimetelloza, colloidal siliconisque dioxide, magnesii glycerin, carmine, morerentur (Ponceau 4R) (E124)

Pharmacological effectus,

Non habet ductum pancreaticum, et extrapancreatic effectus. Pancreatic cancer operatio manifestatur in in titillatione insulin excremento a beta cellulæ pancreatem, extrapancreatic - ut proventus sensum insulin receptores in scopum tela (debitum ad titillatione tyrosine enzyme), insulin, supprimere gluconeogenesis, et glycogenolysis in iecur.

Orci pharmacologicae

Quod C praebet formam Micronized ante adeptionem_max , Secundum substantiam Matching hypoglycemic effectus respicit apicem postprandial hyperglycemia, quae praebet suum effectum in consociatione cum correpta T physiologic_1/2 Reducit periculo hypoglycemia. Glibenclamide potest reduci per singulos dies de 30-40%.

Cautelae

Et cautionem postulari in usum lingua sed torpet syndrome, thyroideum morbo (cum Praesent), hypofunction pedis anterioris glandula pituitam glandula aut cortex, alcoholism, a possibilitate quia aegris senes de hypoglycemia. Requirit regularis medicinae vigilantia. Stricte sequi victu elit. Praesent John non reponere victu. Per curatio non fuit necessarium retrahitur operam et commendatae acies concurrere ad actiones celeritas psychomotor reactiones, diu-terminus maneat in sole. Quid dose est si temperatio corporis animique cultura, mutationem de victu.

Et dosis et modum administrationis de medicamento.

Triticum posuit fretus singulis annis, diabete in gradum severitatem in ieiunio et in GLYCOSA campester II horas post manducans.

In dose est 2.5-15 mediocris mg / die frequency de administratione - 1-3 tempora / die. Take 20-30 momentis ante manducandi. In gustatu maior quam XV mg / die, et non sit in rara casibus, signanter augendae hypoglycemic effectum.

Senes cum initiali, dose est pro aegris I mg / die.

Cum mutantur biguanides glibenclamide ab initiali, dose of 2.5 mg / die. Biguanides Sempronius locassent, et, si necesse est, glibenclamide dose potest augeri ad 2.5 mg omnis 5-6 dies ad ultricies perturbationes metabolismi carbohydratorum. In absentia ultricies in, 4-6 weeks est ex aggregatione illic est eu dolor et glibenclamide biguanides.

3.5 Manin parte effectus,

De glandularum endocrinarum: hypoglycemia, usque ad COMA (proprii laboris uiro Dei de contra progressionem crescit in dosing et insufficiens victu).

Allergic reactiones, cutis temere, prurigine.

De digestivorum: nauseam, fluxus, dolor gravitatem animi et epigas- trico, raro - iecoris munus abnormitates cholestasis.

De systematis nervosi centralis et periphericis nervosi partem, rara - paresis, sensualis motus capitis, lassitudine, infirmitate, vertigine.

Ex hemopoiesis ratio Parcius - turbae ad progressionem de pancytopenia hematopoiesis.

Quemadmodum Dermatological Parcius - photosensitivity.

Speciali mandato ab eo ad usum Manin 3.5.

De morbis utendum Caute in aegris cum renibus et iecur (including historia), et in civitatibus lingua sed torpet, seditiones sint de adrenal, thyroid: Diuturno alcoholismo.

Per curatio requirit magna de iusto sanguine GLYCOSA campester et cotidie urina excretion de GLYCOSA.

Cum progressionem ad hypoglycemia patientes estote si sibi conscius est, GLYCOSA (or sugar) SI intus constituit. Glucosum In illo ignaro, cum is administered / vel glucagon n / k / O aut w / w. Ad salutem necessarium est sensus patiens cibum dives in carbohydrates, ne rursus hypoglycemia.

Glibenclamide aegroti accepto de bibens Vocatus debet abstinere. In Vocatus consummatio ut develop disulfiramopodobnyh causa motus et gravibus hypoglycemia.

3.5 Manin Doctrina Novae Hierosolymae cum aliis medicaménta utíliter.

Amplificatio hypoglycemic glibenclamide actiones, dum modo applicanda servandi beta-blockers, anabolic agentibus, allopurinol, cimetidine, clofibrate, cyclophosphamide, izobarina, MAO inhibitors, sulfonamides agens longum, salicylates, chloramphenicol, tetracyclines, continet ethanol, pendet.

Diminuatur actiones glibenclamide maturationis et altioris intellectionis hyperglycemia possunt in usum barbiturates, chlorpromazine, phenothiazines, phenytoin, diazoxide, acetazolamide, glucocorticoids, Simpaticomimetico agentibus, glucagon, indomethacin, excelsum doses nicotinate, contraceptives ad ingestion et estrogens, saluretics, thyroid Hormones salium Lithium , altum gustatu de laxatives.