Quod pharmacum Kefsepim: ad usum instructiones

Indicia ad usum medicamento Kefsepim Sunt;
- pneumonia (gravibus ad moderari) fecit a Streptococcus pneumoniae (haud exceptis causis simul concurrentibus opus est Bacteremia Association) Pseudomonas aeruginosa, Propionibacterium spp Moraxella catarrhalis aut ,.
- urinariorum tractu infectio (interdum eget et simplex)
- infectiones mollis cutis et tela,
- multiplex Infectiones intraabdominal (in cumulative cum metronidazole) fecit in Mus, Moraxella catarrhalis, Pseudomonas aeruginosa, Propionibacterium spp ,.
- processus developed in background de VIDH infectio nominari solet (exampla: lingua sed torpet neutropenia)
- cohibitionem infectiones durante surgery abdominis;

Parte effectus,

De digestivorum, deiectio, nausea, vomitus, constipation vel abdominis dolor, DYSPEPSIA,
Cardiovascular systema, pectore dolor, tachycardia,
Allergic reactiones, prurigo, cutis temere, anaphylaxis, febrem,
Systematis nervosi centralis, capitis, SYNCOPA, nocturnae vigiliae, paresthesia, anxietatem, confusione, multum discerpens
Respiratoriorum, tussis, faucium, brevitas spiritus;
Locus reactiones: Cum administratum intravenously - Phlebitis, intramuscular - rubore deformes et teneritudinem nimiam ad situm iniectio,
Alterum asthenia, sudorem vaginitis, periphericis tumor retro dolore leukopenia, neutropenia auctum prothrombin tempore

Graviditate

Uti de pharmacum Kefsepim durante graviditate potest esse nisi in his casibus, ubi beneficia in animo praevaleat ut potential periculum, mater ad tractus infantem educit.
Necessitate et usu decernere fine lactationis ubere.

Commercio cum aliis medicaménta utíliter

Secundum altum gustatu de eodem medicamento aminoglycosides KefsepimOportet proxime Monitor renum munus et propter potentiale nephrotoxicity ototoxicity Meningitis de antibiotics. Nephrotoxicity attendendum est simul cum aliis application cephalosporins quae urinae movendae sunt, ut furosemide. Nonsteroidal anti-inflammatione medicinae, tarditatem in excretion de cephalosporins, ad augendam periculo sanguinem. Kefsepim retrahitur I ad XL mg / ml. compatitur parenteral solutions: 0.9%, V% quod X% GLYCOSA solutio sodium chloride in infusione injectable solutionem, solutio sodium lactate 6M iniectio, et 0.9% V% GLYCOSA solutio sodium chloride iniectio, Ringer solution et lactatum est V% dextrose iniectio. Ad vitare possibile medicamento interactiones cum aliis medications, solutions Kefsepim medicamento (et aliis maxime beta-Lactam; Mécanisme) eodem tempore administratum esset, ne cum metronidazole solutionibus, vancomycin, gentamicin, tobramycin sulfate et netilmicin sulfate. In casu de appointment cum haec medicinae est medicamento Kefsepim dicendum existimabat omnem solum antibiotic.

Forma;

quia pulveris solution ad intravenous et administrationis intramuscular

qui phialam suam contineat:

nomine

Indeque judicare poteris, g

0,5 g

I g

Cefepime dose monohydrate, secundum cefepime

(Sursum ad pH 4.0 ad 6.0)

inde est albus color pulveris in flavo-album.

Pharmacological effectus,

Pharmacodynamics

Lato spectro antibiotic cephalosporin est Cefepime de agendi. Cefepime vetat obscura in synthesis de bacterial murum proteins cellula, late placerat bactericidal actionem in Asia, Asia-positive et negative bacteria, inter III et generation cephalosporin aminoglycosides plerisque culturis repugnant antibiotics talis ut ceftazidime.

Est maxime repugnant Cefepime hydrolysa beta lactamases habet affinitatem ad inferiora et penetrat cito cellas lactamases beta-gram negans bacteria.

Atqui cefepime habet affinitatem ad penicillin nimis altum dapibus-binding (PBP) type III, altos et affinis - ad II PSB generis, affinitate ac tam moderatum imperium - 1a ad PSB types et 16. Cefepime habet bactericidal actio contra est ampla Bacteria.

Cefepime activae est Micro-organizati in sequentibus:

Staphylococcus aureus (including modos, quod proferunt beta-lactamase), Staphylococcus epidermidis (including modos, quod proferunt beta-lactamase), alios modos Clostridium sp., Complectens Staphylococcus, Staphylococcus aureus Streptococcus pyogenes (Streptococcus Group A), Streptococcus (Streptococcus Group B), Mycoplasma pneumoniae (including modis reluctans in medium penicillin - Bacteria ug de 0.1 ad I / g), alii beta-hemolytic Clostridium sp. (Groups C, G, F), Mycoplasma bovis (Group D) Bacillus spp. coetus viridians

nota: Enterococci in plerisque culturis, eg, Bacillus cereus, ut methicillin obsistens Staphylococcus aureus et maxime repugnant antibiotics et cephalosporin inter cefepime.

Calcoaceticus Streptococcus pneumoniae (substrain anitratus, lwofii)
Aeromonas hydrophila,
Capnocytophaga spp.
Citrobacter spp. (Citrobacter diversus Complectens, Citrobacter freundii)
Corynebacterium glutamicum ATCC:
Propionibacterium spp. (Complectens Propionibacterium cloacae, Aerogenes, Propionibacterium sakazakii)
Mus,
Gardnerella vaginalis,
Haemophilus ducreyi,
Fusobacterium (including versu producendo beta-lactamase)
Haemophilus parainfluenzae, Hafnia alvei,
Clostridium sp. (Moraxella catarrhalis Complectens, oxytoca Bifidobacterium, Lactobacillus ozaenae)
Legionella spp.
Morganii Morganella,
Moraxella catarrhalis (Branhamella catarrhalis) (beta-lactamase inter modos producendo)
Ducreyi (including versu producendo beta-lactamase)
Atypical, Mycobacterium
Sodalis agglomerans (formerly known as Propionibacterium agglomerans)
Proteus consueta sp. (Caeruleus Proteus mirabilis Complectens Proteus vulgaris)
Providencia sp. (Providencia rettgeri Complectens, Providencia stuartii)
Yersinia pseudotuberculosis IP sp. (Yersinia pestis Complectens: Yersinia, Pseudomonas stutzer)
Propionibacterium spp.
Serratia sp. (Complectens Serratia marcescens, Serratia liquefaciens)
Bacillus spp.
Pestis,

illud: multis modis agendi cefepime Stenotrophomonas maltophilia olim et quae Xanthomonas maltophilia Pseudoalteromonas maltophilia).

anaerobes:

Bacterium spp.
Clostridium perfringens;
Fusobacterium spp.,
Mobiluncus spp.
Peptostreptococcus spp.
Melaninogenica enterococcus faecium (quae Bacterium melaninogenicus)
Pylori spp.

illud: Cefepime ullo conatu sedentes in Bacteroides fragilis est et Cardiobacterium hominis. Secundarium resistentia ad Micro-organizati cefepime develops lente.

Farmacocinética

Variis temporibus in a sanus adultorum concentration plasma ex media cefepime post XXX minuta ad XII horas ad unum infusum intravenous et maximam concentratione (C_s) Tu autem in dedit sub mensa.

Cefepime average curam in crebris magnarum super plasma (PG / g) Post intravenosa.